When we created Noom’s GLP‑1Rx Program we started from a simple premise: the “right” dose of medication is the lowest dose that delivers maximal long-term health gains.
Data demonstrates that as many as 74% of people experience side effects on standard GLP-1 dose schedules, typically gastrointestinal side effects. And these side effects are a major reason for medication discontinuation.
With the Microdose GLP-1Rx Program, we set out to virtually eliminate side effects for the vast majority when combined with Noom’s powerful GLP-1 Companion, so that more than 70% of people would encounter no side effects.
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By combining individualized titration protocols with daily, app‑based behavior change, we help members achieve sustainable weight loss with a fraction of the drug exposure and therefore a fraction of the side effects seen in conventional protocols. This is the core of Noom’s GLP-1Rx Program, which already seeks to minimize side effects through our SmartDose protocol while maximizing outcomes with integrated support for healthy habits.
Noom’s Microdose GLP-1Rx Program is based on several scientific principles:
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Stay on top of your wellness journey with the latest Noom news, thoughtful articles, and a healthy dose of inspiration delivered right to your inbox.- Self-efficacy boosts success. Medication makes it easier to adopt healthy habits, while healthy habits improve health outcomes. Members who engage with Noom’s GLP-1 Companion achieve success, as measured by 10% weight loss by month 4, at twice the rate as those who are not engaged in the companion app. Noom members on GLP-1s actually log more meals, weigh in more often, and log more exercise by their second month than those on Noom without a GLP-1.
- Strong weight loss outcomes at lower doses are both achievable and well established in the literature. A 2,700‑person real‑world study presented at the 2025 European Congress on Obesity showed an average 16% weight‑loss over 64 weeks at microdose levels of semaglutide. Meanwhile, another study in The New England Journal of Medicine shows just 33% of the dose of one popular GLP-1 drove 72% of the weight loss at week 72 with a lower side effect profile.
- The benefits from GLP-1s extend beyond weight. Recent analyses presented at the National Lipid Association’s 2025 Scientific Sessions highlighted cardiovascular, renal, and metabolic gains from GLP‑1s that appear partly independent of the amount of weight loss. Other studies show a similar impact on inflammatory markers independent of weight loss. Meanwhile, other studies demonstrate a reduction in compulsive behaviors like drinking and gambling.
Taken together, the evidence is clear: smaller, smarter dosing, paired with sustainable behavior change, can unlock outsized health benefits.
Noom’s Clinical Philosophy for GLP‑1s
At Noom, every GLP‑1 prescription begins with personalized care: a board‑certified clinician reviews each member’s medical history and health goals before writing the first script. The guiding principle is “find the lowest effective dose first.”
Instead of escalating dosages on an arbitrary schedule, our physician-designed protocol increases or decreases doses based on a member’s evolving progress and side effects. To further support health, the program weaves in nutrition coaching, protein‑forward meal guidance, and resistance training to minimize side effects and preserve lean muscle mass.
Medication alone cannot rewrite habits, so our clinical protocol is inseparable from daily cognitive‑behavioral lessons, AI‑supported food logging, gamified habits and tracking, and support from a health coach. Ultimately, weight loss is not the destination but a vehicle for a larger goal: adding healthy, vibrant years to life.
What is a Microdose?
Noom defines a microdose as a dose of medication that is a fraction—25% or less—of the typically prescribed maintenance dose. Noom’s microdose dosing schedule is not one-size-fits-all. It accesses doses lower than the usual starter doses as well as additional doses up to 25% of the standard maintenance dose.
Within that band, the exact dosage schedule is established one member at a time: our physician-prescribed protocol, aided by Noom’s SmartDose experience, guides members to the lowest dose that achieves health goals. Factors influencing that decision include BMI, weight loss speed, side effect profile, and other health data.
While many eligible GLP-1 users are deterred from starting medication due to fear of incurring side effects, others are challenged by high medication costs. Among those who do start using GLP-1s, over 50% stop due to costs, and as many as 36% stop due to side effects.
Noom’s Microdose GLP-1Rx Program bridges this gap by offering a more personalized, tolerable path to treatment. It is built on a guiding principle of using the lowest effective dose first. Rather than increasing medication on a fixed schedule, Noom’s physician-approved and designed protocol adjusts dosing based on each patient’s individual progress and response. This approach enables personalized care that supports meaningful weight loss while minimizing side effects and helping more people adhere to the treatment.
Noom Microdose GLP-1Rx Program includes:
- Microdose GLP-1 medication, if prescribed
- Full access to the Noom GLP-1 Companion educational program
- 24/7 access to message doctors and care coordinators
- Noom premium 1:1 health coaching
- Prescription home delivery
- Pricing: $119 to start and then $199 per month
A Variety of Programs to Meet Patient Need
While we believe a Microdose program is appropriate for many people, many others will benefit from more intensive GLP-1 therapy, which is why Noom continues to offer a variety of programs, including our standard Noom GLP-1Rx Program, as well as telehealth support for name-brand GLP-1s, whether cash pay or insurance covered.
In fact, the share of brand-name and generic GLP-1s that Noom prescribes has increased by 2.9x since May 1st. In the Noom program, a doctor always determines whether medication is appropriate and which medication to prescribe to each patient, whether brand name, generic, or personalized via a 503a pharmacy. The Noom program is not one-size-fits-all.
Looking Ahead to Longevity
At Noom, our vision is to add a decade of health span for a billion people. We aim to hasten the transformation of sick care to true health care, to replace one-size-fits-all disease management with personalized, preventive medicine. Today’s launch is our biggest step yet toward achieving our vision.
So much of longevity depends on metabolic health. Noom got its start by creating a proven digital program that addresses the number one barrier for most people to improve health—their habits. Now, with GLP-1s, our aim is combination therapy that drives metabolic recalibration and metabolic resilience via medication plus healthy habits. We have seen that GLP-1s boost the ability for members to develop self-efficacy with Noom—people see and feel success, and that success enables healthy habits to take root. GLP-1s transform motivation. Good habits become identity and promote human flourishing.
This is a modern treatment for the ills of modernity. We help people sustain a healthy weight in a food environment engineered for dopamine-hits and excess consumption. Helping people limit compulsive eating and drinking, motivate movement, and reduce chronic inflammation— which we know GLP-1s can do—we promote a higher quality life.
With a fraction of the dose, Noom’s Program can achieve meaningful weight loss, accompanied by a markedly improved side effect profile that’s designed to limit discontinuation and encourage persistence. With a price of just $119 to start, the Noom Microdose GLP-1Rx Program democratizes access while ensuring that side effects are not a barrier to care.
