What is Noom’s Proactive Health Microdose GLP-1Rx Program?

Longevity and metabolic health used to feel like niche topics reserved for elite athletes or biohackers. Today, more people are realizing that staying well as we age means understanding what’s happening inside our bodies—not just what we do on the outside. That’s why so many of us are asking a new question: What should I be paying attention to if I want to feel good today and stay healthy longer?

Research shows that the answer goes beyond “eat right and exercise more.” Those habits still matter, but your biology influences how your body responds, and those responses can change as you age. What works at 25 might not work at 45, even with the same effort.

Noom’s Proactive Health Microdose GLP-1^Rx Program was designed with that in mind. It pairs microdoses of GLP-1 medication with at-home biomarker testing and Noom’s AI-powered longevity coaching to support the systems that matter most for long-term health—your brain, heart, and metabolism. The goal is to help you understand what’s happening inside your body and make habits that truly work for you.

What’s included

The program includes three key pillars: 

1. Microdose GLP-1 medication: Small, personalized doses of GLP-1 therapy designed not for weight loss, but for wellness and longevity. Emerging research suggests GLP-1s may calm inflammation and support cardiovascular and metabolic health, with potential benefits for organs like the liver and kidneys—all while helping stabilize appetite and energy.
2. At-home Noom Biomarkers test kit: The program monitors 17 biomarker-based health insights (14 biomarkers and 3 ratios determined with these biomarkers for risk assessment) that track your metabolic, cardiovascular, and hormonal health in addition to measuring inflammation over time. 
3. Behavioral support through Noom’s digital longevity companion: This is where you’ll learn science-backed microhabits that make health improvements stick. It’s not about quick fixes; it’s about clarity, steady guidance, and building a realistic path toward feeling and aging better.

Whether your goals include aging well, improving daily energy, maintaining optimal body composition, or staying ahead of future health risks, this program is designed to offer personalized, proactive care grounded in science.

Who is Noom’s Proactive Health Microdose GLP-1^Rx Program for?

This program is open to people with a BMI of 21 or higher, who are looking to optimize their whole-body health. Eligibility is determined by a licensed clinician based on your health history.

Who can’t use the program?

This program isn’t appropriate for everyone. Individuals with a BMI under 21, those who are pregnant or breastfeeding, using insulin, managing an active eating disorder, or with certain thyroid or pancreatic conditions may not be eligible. That’s why every member completes a brief clinical review before starting. If the program isn’t the safest option for you, a clinician will explain why and walk you through what to do next.

The Longevity Loop: Turning insight into action 

Noom’s new program is built around the idea that your body can give you information about the direction of your long-term health. When you know how to read it, you can make smarter choices. Noom Proactive Health Microdose GLP-1^Rx Program connects those indicators to action, creating a loop that helps you understand what’s happening inside your body, respond to it, and see real progress over time.

We call this the Longevity Loop, and it works like this:

Test → Treat → Track → Optimize

• Test: You start with a simple at-home blood test using the Noom Biomarkers Test Kit. It checks key biomarker-based health insights linked to energy, metabolism, inflammation, and longevity.
  
• Treat: Your clinician may recommend a low weekly dose of semaglutide to support appetite regulation, metabolic stability, and healthier inflammatory patterns.
  
• Track: Inside the Noom app, you keep an eye on things like weight trends, energy, habits, and how you feel day to day. This helps you and your Care Team understand how your body is responding.
  
• Optimize: Every four months, you’ll re-test your biomarkers. This closes the loop and gives you a clear picture of what’s improving, what still needs support, and how to fine-tune your plan moving forward.
  

It’s a continuous cycle designed to help you stay ahead of future health concerns—not just react to them—so you can feel better now and build a stronger, healthier future.

The medication: Microdose GLP-1 plus glycine 

Now that you know how the overall program works, let’s look at the medication itself and why Noom uses a microdose approach.

Microdosing means using a small amount of semaglutide, starting at 0.05 mg and increasing up to 0.2 mg once per week. These small doses are designed to support steady blood sugar, calmer hunger patterns, and healthier inflammation levels.

How the microdose works in your body

At low doses, semaglutide works with your GLP-1 system to gently:

• Steady glucose highs and lows
• Smooth out erratic hunger patterns
• Support healthier cholesterol and triglyceride levels
• Decrease markers of inflammation
• Improve vascular and metabolic function over time

These effects have been observed in people without diabetes or BMIs over 30, which is why GLP-1s have become a major focus in longevity and metabolic research. Read more about how GLP-1s are being studied for their potential benefits to heart health, kidney and liver protection, brain health, and longevity.

What is glycine? 

Our semaglutide ​​formulation includes glycine, an amino acid tied to muscle preservation, gut comfort, and lower inflammation. Glycine is gaining attention in longevity research because it may:

• Support lean muscle maintenance
• Help regulate inflammation and oxidative stress
• Protect the lungs, brain, stomach, and intestines
• Support metabolic function

This formula is designed for people who want long-term health benefits but also want to maintain (and even build) muscle, something that’s central to healthy aging.

How you take it

You’ll use a tiny subcutaneous needle to administer. If it’s your first time injecting medication, your Care Team will walk you through it.

Everyone starts at 0.05 mg, and it will be adjusted up to a maximum of 0.2 mg if needed. Your clinician may adjust your dose depending on your lab results, tolerance, weight stability, and goals. 

Side effects 

Microdosing is designed to minimize side effects; however, some people may notice:

• Mild nausea
• Constipation
• Occasional fatigue or reflux

The gradual dosing schedule makes it easy to adjust, pause, or lower the dose.

The diagnostics: Noom at-home biomarker kit

Many early signs of aging happen quietly. Inflammation rises slowly, cholesterol patterns shift, and hormones change in ways that affect energy, sleep, and body composition—often years before you feel anything. Tracking biomarker-based health insights helps you catch those changes early so you can support your body with the right habits and plan. That’s what makes this program proactive: you’re learning what’s happening beneath the surface instead of waiting for symptoms.

What makes Noom’s test kit different

There’s no lab visit or waiting room. You place the blood collection device on your upper arm, press a button, and it collects a small sample through a gentle vacuum—most people say it’s painless. Drop it in the prepaid envelope, send it back, and your results arrive in about a week.

What the panel checks

This program focuses on 17 key biomarker-based health insights that give a clearer picture of how your body is aging over time, including:

• Inflammation & recovery
  
  • High-Sensitivity C-Reactive Protein (hs-CRP)  – This is a marker of inflammation that’s closely linked to heart health, recovery, and long-term disease risk.
  • Vitamin D – This vitamin is essential for immune function, bone strength, and healthy cell repair. Because levels often drop in winter or low-sunlight climates, many people need supplements to stay within a healthy range.
  • Vitamin B12 – This supports red blood cell production, nerve health, and steady energy. It’s found naturally in animal foods like meat, eggs, dairy, and fish, which is why people following vegetarian or vegan diets are often deficient without fortified foods or supplements.
    
• Cardiovascular health
  
  • Apolipoprotein B (ApoB) – This measures the number of particles that can contribute to plaque in your arteries, making it one of the clearest indicators of heart health.
  • Lipoprotein (a) (Lp(a)) – This is a genetically driven cholesterol particle tied to lifelong cardiovascular risk.
  • Full lipid panel – This full cholesterol profile shows how your body processes and transports fats, and gives a clearer picture of your heart and metabolic health. It includes:
    • Total cholesterol
    • Low-density lipoprotein (LDL-C)
    • High-density lipoprotein (HDL-C)
    • Triglycerides
  • Total Cholesterol/HDL-C ratio – This ratio shows how balanced your cholesterol is overall and is often a stronger predictor of heart disease than total cholesterol alone.
  • LDL-C/ApoB ratio – This ratio helps identify whether your LDL particles are mostly small and dense (higher risk) or larger and less atherogenic (lower risk), offering deeper insight beyond standard LDL-C levels.
    
• Metabolic health
  
  • Hemoglobin A1c (HbA1c)  – This number shows how well your body has managed blood sugar over the past 3 months and is one of the key markers used to diagnose and monitor diabetes.
  • Triglycerides – A measure of the fat circulating in your bloodstream—higher levels are linked to insulin resistance, metabolic issues, and cardiovascular risk.
  • Triglycerides/HDL ratio – This ratio offers insight into insulin resistance and cardiometabolic risk by comparing blood fats that store energy (TG) to the HDL particles that help clear them.

• Hormones
  
  • Total testosterone – Found in both men and women, total testosterone influences muscle, strength, drive, and daily energy.
  • Estradiol (E2) – This form of estrogen is present in both women and men. In women, levels change across the lifespan with the biggest drop during menopause. Estradiol supports bone health, cardiovascular function, reproductive health, and metabolic balance.
  • Luteinizing hormone (LH) – This hormone helps regulate reproductive hormones and overall hormonal balance in both men and women.
  • Dehydroepiandrosterone sulfate (DHEA-S) – This adrenal hormone supports stress response, hormonal balance, and overall vitality.

Together, these biomarkers give you an in-depth picture of your metabolic, cardiovascular, hormonal, and inflammatory health—so you’re not just tracking disease, you’re tracking how well you’re aging.

How do I sign up?

Getting started with Noom Proactive Health Microdose GLP-1^Rx is easy. Here’s how it works: 

Qualification & intake
A quick online medical review by a clinician to confirm the program is safe and appropriate for you.

The biomarker kit
Your first at-home Noom Biomarkers kit arrives. This initial test sets your starting point and establishes your baseline health metrics.

The prescription
If medication is appropriate, your microdose semaglutide is shipped to you in climate-controlled packaging with syringes and simple instructions.

The app experience
Inside the Noom GLP-1 Companion App, you can track your protein, hydration, habits, and side effects, and access Muscle Defense™ to support strength and healthy aging.

The Longevity Loop
Every four months, you repeat your biomarker test to see what’s improving, what needs adjusting, and how your habits and dose are shaping your long-term health.

Pricing and accessibility

• What’s included: The subscription includes clinical care, microdose GLP-1 medication (if prescribed, along with biomarker testing if you qualify for the medication), and full in-app support.
• The cost: $149/month, which is billed as $596 per four-month cycle.
• Value comparison: This pricing structure is far more accessible than paying separately for specialty labs, concierge longevity visits, and compounded GLP-1 medication.

Frequently asked questions about Noom Proactive Health Microdose GLP-1^Rx

Is this a weight-loss program?
No. It’s designed for metabolic stability, inflammation support, and healthy aging, not weight loss. If you are interested in weight loss, consider checking out Noom GLP-1^Rx Program.

What if the medication doesn’t feel right for me?
Your clinician can adjust your dose, pause treatment, or help you continue the program using biomarker-based guidance alone.

How long until my biomarkers start changing?
Some people notice improvements within a few months. Others see changes over a longer timeline. That’s why regular re-testing is part of the plan.

Do I have to be “into biohacking” for this to work?
Not at all. You just need curiosity about your health and interest in taking small, actionable steps.

How Noom’s Proactive Health Microdose GLP-1^Rx program can improve your life

Living longer—and in better health—starts with understanding what your body needs as it changes. Noom’s Proactive Health Microdose GLP-1^Rx Program makes that easier by pairing microdose GLP-1s with regular biomarker testing and steady habit support. It gives you a clear picture of what’s happening inside your body—and a reliable way to adjust your plan using real data, not guesswork.

With insight into your metabolic, cardiovascular, hormonal, and inflammatory health, you can make choices that move those biomarkers—and your wellbeing—in the right direction over time.

And as your biomarkers evolve, the program evolves with you. Whether your focus is aging well, keeping your energy up, maintaining muscle, supporting heart health, or simply having more control over your long-term wellbeing, you’ll have a clear path forward.

This is proactive health in action: Test what matters. Support your biology. Track your progress. Refine as your body evolves. 

It’s a grounded, science-backed, and empowering way to care for your future health—starting today.

Ready to see if you qualify? Check eligibility now.